Masteron is, to be honest, my favorite Anabolic/Androgenic Steroid (AAS). For many years, this compound was unavailable to the average athlete; it was frequently counterfeited, often very expensive, and almost never available on the black market. The most common form of this product, as manufactured by major pharmaceutical houses, is 50mg/ml ampules with either 1-2mls per amp (or vial). Needless to say, these products used to be the only game in town, and since this drug was a particularly sought-after compound for bodybuilding contest preparation, it´s price made it prohibitive for all but the highest level bodybuilders.
Masteron is a derivative of DHT (as you can tell from its chemical name: 2a-methyl-dihydro-testosterone propionate), but what they fail to tell you is that DHT and its derivatives are commonly used in treatment of certain forms of breast cancer (see the etymology here: MASTectomy, gynocoMASTia, MASTeron, get it?). Masteron is not clinically used for weight gain (as is common with most steroids), so this makes it a very unique steroid from that perspective. Unfortunately, much of the information on Masteron available in medical journals doesn´t focus on weight or strength gain or even fat loss, for those reasons. Most information on Masteron focuses on it´s use in treating certain forms of breast cancer, and it does this reasonably well.(4)(5) To give you an idea, Masteron + Tamoxifen actually fared better than Chemotherapy for immediate objective responses from patients (8).So? What does this tell us? Well, this makes it a very exciting drug for a lot of reasons. Clearly it won´t aromatize at all nor will it have progesteronic sides, remember, Nolvadex (and most ancillaries) are used to reduce estrogen for breast cancer patients, so a drug used to treat breast cancer obviously wouldn´t convert to estrogen...and in fact Masteron may interact with the aromatase enzymes to inhibit aromatization of other steroids into estrogen, and may additionally interact with estrogen (as a "blocker" of sorts) at the receptor site. (4)(5) This is how it helps to combat breast cancer, obviously, but this could also be part of the reason that Masteron is considered a "cutting" or "Pre-contest" drug. Masteron may actually be very useful for combating estrogenic/progesteronic side effects yes, you read that right, if you include Masteron in your cycle, you may not need other "ancillary" drugs like Arimidex or Letrozole). Hence, much like Proviron, Masteron could be used as an anti-side-effect-drug (remember, most ancillary drugs we use to combat estrogenic sides, like nolvadex, letrozole, and arimidex were originally developed to combat breast cancer...and thats exactly what Masteron was developed and used for). Along a similar line, being a DHT (DiHydroTestosterone) derivative, it´s got a very nice ability to add muscle hardness to an already lean physique, remember, Masteron has a deceivingly low anabolic/androgenic ratio, but since DHT is 5x as androgenic as testosterone and has a 3-4x higher affinity to receptor sites, Masteron provides a lot of "bang for the Buck" when examined on a Mg for Mg basis.
In my experience, as well as many others, Masteron is a stronger androgen than it appears on paper, and and this could cause increased aggression. As we know, higher androgens also produce that "hard" look prized by competitive BB´ers and as we all know, androgens also promote lypolysis (fat loss). The effects of Masteron, in that way are consistent with the documented effects of (somewhat heavier) androgens to decrease lipoprotein lipase and upregulate -adrenergic receptors on adipocytes, which would inhibit the accumulation of lipid (fat) and enhance the efflux of lipid from these cells in response to catecholamines (1)(2)(3). So, like I said previously, don´t let Masteron´s deceptively low Anabolic:Androgenic ratio fool you, it helps eliminate fat as well (if not better) than much more highly scored androgens, in part due to its being a derivative of DHT. This reduction in fat and rise in aggression (making workouts more effective) could be beneficial for people competing in a sport or who are on a reduced calorie diet. Sounds pretty good, right? Unfortunately, being a DHT derivative means that it can have certain undesirable sides as well (acne, hairloss, prostate enlargement, etc& you may want to consider using Finasteride with this drug). Water retention (and increased danger of high Blood Pressure) with this compound is virtually nil, and liver toxicity is not much of an issue either. Really, you can take heaps of this stuff...the maximum therapeutic dose is pretty high: 167mgs/kg-bdywt/day. So that´s 167mgs per day, every day of the week, for a 220lb person...and that´s not considered excessive by the FDA...who hasn´t been very traditionally liberal on dosing protocols. So clearly, up to that dose is very safe for almost anyone. DHT has a bad reputation for causing prostate hypertrophy, acne, and hairloss& but most people I´ve talked to find that reputation to be mostly undeserved at least in the case of Masteron.
Remember that year that the Chinese National Swimming Team (women´s) were kicking everyone´s ass? Or the year that the German National Swimming Team (again, I´m talking about women) were taking all those Gold medals? They were all using a form of DHT or a derivative, possibly Masteron. The German Women had very deep voices, which leads me to believe that Masteron´s virilizing effects on women could be very bad (there was a famous/funny interview where the interviewer implied that they all had deep voices, and one of them replied "Ve came here to svim, not to sing."). Hence, I feel Masteron is a great drug for any type of athlete, but possibly not for women (at least not at high doses... perhaps 50mgs/E3D is appropriate). Sorry girls...you can have a go with this drug, but keep the doses low.
Stacking Masteron? Well, I´d say that your best bet is with test, of course but really, due to Masteron´s reasonable binding to the Androgen Receptors and its high androgenic properties, almost any cutting drug (Tren, Anavar, etc... ) could be included in a cycle with it for an efficient stack. I have a feeling that due to Stanozolol´s (Winstrol) non-AR mediated effects, and its ability to reduce SHBG, a stack including both of these drugs would be very synergistic. However, don´t forget the Testosterone, as Masteron will reduce your own natural testosterone levels (9), and since you are going to have to inject Masteron Every Other Day at least (100mgs EOD is the lowest dose of this stuff I´d consider using), you might as well stack it with Testosterone Propionate, and possibly injectable Winstrol (and/or maybe Tren Acetate, if you´re inclined to use a lot of compounds in the same cycle& and I know I am& ). Eq is another popular choice to stack with Masteron.
I´d say that optimum effects of this stuff are found with 4-500mgs/week (based on conversations I´ve had with people who have used Masteron, as well as my own results). I happen to have a friend who has gone up to 600mgs/week with Masteron and didn´t feel that it provided significantly better results than 400-500mgs per week. I think, for maximum cost effectiveness, 400mgs per week is ideal. It´s also important to remember to spread those shots out on an every other day basis, as the Masteron I´m talking about here is the Propionate version, and as such, requires more frequent dosing. Of course I know there is a version of Masteron with an enanthenate ester dosed at 200mg/ml being produced by a very good Underground Lab (I personally used the "alpha" version, as a sort of Human Guinea Pig almost a year ago), but that´s not the version of Masteron I´m talking about in this profile. In addition, there is another form of Masteron out there: Drostanolone (base), yeah, that´s right, Masteron without an ester. It´s called Dromostan and it´s made by the Xelox Company. I´ve never tried this version, and don´t know anyone who has, but it´s my suspicion that it would be a very potent product, but would need to be injected every day.
If you are looking for this drug from a major pharmaceutical company, I´d caution you to reconsider that route, and go with an Underground Lab instead. There are many very reputable underground labs operating out there, with no known counterfits. On the other hand, genuine Masteron is one of the most difficult drugs to find on the black market, when you´re looking for a "Human-grade" product made by a major pharmaceutical house. In addition, UGLabs commonly offer this product for a very reasonable $50-75 for a 10ml bottle dosed at 100mg/ml. Trying to find the Syntex (or comparable Human-Grade) version of this product will bring a mg for mg cost of 2-5x that amount.
To recap: Masteron is derived from DHT, could be used as an anti-estrogenic drug, clearly it doesn´t convert to estrogen and actually works to reduce it in your body, can possibly cause hair loss and other DHT-related sides, is great for all types of athletes and BB´ers, but not women in high doses, it stacks well with almost anything, is very androgenic, awesome for losing fat and getting "hard", and should be used at around 400-500mgs/week. It´s no surprise that it´s many people´s favorite steroid, mine included.
Molecular Weight: 360.5356
Manufacturer:Syntex, Various Underground Labs
Effective Dose (men):350mgs/week (*100mgs Every other day) to 500mgs/week
Effective Dose (women): 25-50mgs Every other Day to Every Third Day
Active Life:2-3 days
Detection time: 3 weeks