Contrary to what many would expect, this compound is actually only a weak agonist of the androgen receptor (AR), with poor binding. It follows, then, that its value must mostly come from non-AR-mediated effects. It is therefore a Class II steroid. Since it is not very effective in activating ARs, it should be stacked with a Class I steroid that is effective in this regard, such as Primobolan, Deca Durabolin, or trenbolone acetate. There is no point in stacking it with Anadrol, which has similar activity — one ought to simply use the more appropriate drug. With testosterone or Deca, Dianabol is to be preferred; with Primobolan or trenbolone acetate, Anadrol is to be preferred (though Dianabol is still a good choice) because Anadrol does not aromatize. For an oral-only cycle — something I don't recommend — Anadrol is the better choice in my opinion for that also, at 150 mg/day (preferably divided to 3 or 6 doses.)
Methandrostenolone converts to estradiol via aromatase. The amount of this conversion may be reduced by use of Arimidex, or less preferably Cytadren (see previous articles discussing dosage and dose pattern.) Or if the conversion is allowed, Clomid may be used to block adverse estrogenic effects.
Irreversible hoarsening of the voice has been seen in some women from very few tablets of Dianabol: one per day for a few weeks. For this reason, in the 1960s doctors decided to end what had been a fairly common practice of prescribing this drug at one tab per day to women as a "tonic." It is not a good choice for the woman who chooses to use anabolic steroids.
The usual dosing for men is 25-50 mg/day in divided doses, preferably four or five doses. The drug is 17-alkylated and so use should be limited to no more than 6 weeks, and preferably no more than four weeks, with at least an equal amount of time off.